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Written by Benjamin S-B :verified: on 2024-10-10 at 12:20

It turns out that the opposite is the case: MMR deficient cancers have more C>T mutations at CpG! Cancers that loose proofreading of the main replicative polymerase (Pol-ε) have an even higher rate of C>T at CpG. So how can this be?

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