Affected by #NIH and #NFS funding cuts and considering a move abroad? I haven't advertised this yet, but I have fresh funding for 2 senior #postdoc positions in #oxford. If you're into #Cancer #genomics and #epigenetics then get in touch.
Please RT 🙏
[#]FediHire @academicchatter
=> More informations about this toot | View the thread
We think that studying the unique features of the epigenetic landscape of GTD can provide important clues on how immune evasion is accomplished in cancer, and on how epigenetic changes induce a pro-proliferative phenotype. (5/🧵)
=> More informations about this toot | View the thread
This disease is fascinating for many reasons, but one that stands out is that it seems to be entirely driven by epigenetic factors rather than mutations, like most other tumours. So how does this work, and what can it teach us about cancer? (4/🧵)
=> More informations about this toot | View the thread
This is called a "complete hyaditiform mole", and is - in effect - a foreign organism growing like a tumour inside the mother! 🤯 On occasion, these can even spread outside the uterus and form so-called choriocarcinomas. (3/🧵)
=> More informations about this toot | View the thread
GTD is a disease where placental cells grow abnormally in a pregnant woman's uterus. This can happen when an oocyte is fertilised, but subsequently looses the maternal part of the genome 😱 followed by duplication of the paternal set of chromosomes. (2/🧵)
=> More informations about this toot | View the thread
New review paper out, in which we delve into the fascinating world of gestational trophoblastic disease. Never heard of it? Let me fill you in! (a 🧵) #epigenetics #cancer
https://journals.biologists.com/dmm/article/18/1/DMM052010/365465/Gestational-trophoblastic-disease-understanding
=> More informations about this toot | View the thread
Are you into #rustlang and looking for (remote) #work? Want to help #cancer #research? We're planning to add some major features to a CLI app that require some serious software engineering skills. Understanding of stats a big plus, genetics knowledge a bonus. Send me a DM!
(Please RT for reach)
[#]rustjobs #RemoteJobs #Job #jobs
=> More informations about this toot | View the thread
Hive-mind: what #epigenetics and #cancer #genomics conferences should I not miss this year?
I just registered for https://www.ccg2025.eu, and plan to go to https://broadinstitute.swoogo.com/mits2025 - any other great meetings out there? I feel there's a gap in the market for a really comprehensive event calendar for biology conferences...
=> More informations about this toot | View the thread
Calling out to other Oxford-based academics: is anyone aware whether the university has made any announcement whether it plans to close it's presence on Xitter? Who would be interested in putting together a letter to the VC/congregation to do so? @academicchatter
=> More informations about this toot | View the thread
Interesting #genomics meeting in #Amsterdam being advertised over on 🦋:
https://bsky.app/profile/ecuppen.bsky.social/post/3lffcgepgps2z
Prove that you don't travel by plane and only use public transport, and they will give you a 30% discount on the registration fee!
=> More informations about this toot | View the thread
Fascinating story. The fact that his girlfriend is Ukrainian would be too much for a novel. Reality can be stranger than fiction:
https://www.theguardian.com/world/2025/jan/04/anas-modamani-syrian-refugee-selfie-angela-merkel
=> More informations about this toot | View the thread
This sentence sums up the issue, from a legal and moral (/Kantian) perspective:
"The right to die, for some, will - inexorably and inevitably - become the duty to die for
others."
I do agree with her that on this basis alone, despite the importance of self-determination and the understandable desire of some individuals to end their suffering, the provision of death can never be a function of the state, or even be something that the state facilitates.
=> More informations about this toot | View the thread
There's intense debate in the UK right now about legalising assisted suicide. Several politicians have come out on different sides, but I found this letter from Shabana Mahmood (via @TheGuardian) particularly powerful:
=> More informations about this toot | View the thread
Just changed my bsky profile to link to my mastodon account - let's hope someone might actually listen and move here 🤷🏼♂️
=> More informations about this toot | View the thread
This paper wouldn't exist without the freely available mutation data from MMR deficient patients and various other open datasets. "Open Data" matters. Lastly: we could never have proven the point without working very closely with experimental scientist. This was a real team effort, everyone bringing their insights, tools and skills to bear on the problem.
Anyway, I'm incredibly proud of this paper, and so happy to finally see it out in the world.
End/🧵
=> More informations about this toot | View the thread
To give some perspective: from conception to publication, this project spanned over 9 years! Marketa Tomkova, who made the initial observation, was a PhD student in my group when we started. She now leads her own group. Sometimes, you have to be very patient in science, and lucky to have enough funding from different sources to finish a project.
12/🧵
=> More informations about this toot | View the thread
By either methylating or not methylating the ROI, we can then test if Pol-ε makes more errors when copying methyl-C than C.
If you've read this far, the big reveal is not going to be too surprising: Pol-ε, even with proofreading intact, often puts an A opposite methyl-C!
11/🧵
=> More informations about this toot | View the thread
Michael set up an assay that he calls Polymerase Error Rate sequencing (PER-seq): a known region of interest (ROI) is made single-stranded, then filled in by reconstituted human Pol-ε in a cell-free setting, so that no repair or other cellular processes can interfere. Through a combination of cleanup steps, double-barcoding of single molecules and a lot of clever computational filtering, we are able to detect replication errors in single molecules!
10/🧵
=> More informations about this toot | View the thread
Fortunately, Skirmantas Kriaucionis's group, and especially his amazing postdoc Michael McClellan, came up with an idea of how to experimentally test our hypothesis!
9/🧵
=> More informations about this toot | View the thread
As is often the case, nobody wanted to believe such a crazy hypothesis that completely overturns a paradigm that's printed in every molecular biology textbook, at least not based on just some re-analysis of public cancer genomics data. We published our results in DNA Repair, but few people ever read that paper.
https://doi.org/10.1016/j.dnarep.2017.11.005
8/🧵
=> More informations about this toot | View the thread
=> This profile with reblog | Go to bensb@genomic.social account This content has been proxied by September (3851b).Proxy Information
text/gemini