Ancestors

Written by Hannu Ikonen, MD on 2025-02-01 at 22:48

PASC Prevalence (Long Covid):

By quartiles of a year:

"Based on different assessment or follow-up timepoints after acute COVID-19 infection, PCS prevalence estimated at ≥ 3rd, ≥ 6th, and ≥ 12th months timepoints were each 45.06% (95% CI: 41.25–48.87%), 41.30% (95% CI: 34.37–48.24%), and 41.32% (95% CI: 39.27–43.37%), respectively."

By region:

"Based on continental regions, pooled PCS prevalence was estimated at 46.28% (95% CI: 39.53%-53.03%) in Europe, 46.29% (95% CI: 35.82%-56.77%) in America, 49.79% (95% CI: 30.05%-69.54%) in Asia, and 42.41% (95% CI: 0.00%-90.06%) in Australia."

By the two year point:

"This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19."

[#]PASC #LongCovid #Covid19

https://www.journalofinfection.com/article/S0163-4453(23)00590-X/fulltext

https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-024-19264-5

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Written by Hannu Ikonen, MD on 2025-02-01 at 22:50

Year 3 numbers:

"Here we built a cohort of 135,161 people with SARS-CoV-2 infection and 5,206,835 controls from the US Department of Veterans Affairs who were followed for 3 years to estimate risks of death and PASC.

Among non-hospitalized individuals, the increased risk of death was no longer present after the first year of infection, and risk of incident PASC declined over the 3 years but still contributed 9.6 (95% confidence interval (CI): 0.4–18.7) disability-adjusted life years (DALYs) per 1,000 persons in the third year.

Among hospitalized individuals, risk of death declined but remained significantly elevated in the third year after infection (incidence rate ratio: 1.29 (95% CI: 1.19–1.40)).

Risk of incident PASC declined over the 3 years, but substantial residual risk remained in the third year, leading to 90.0 (95% CI: 55.2–124.8) DALYs per 1,000 persons.

Altogether, our findings show reduction of risks over time, but the burden of mortality and health loss remains high in the third year among hospitalized individual"

https://www.nature.com/articles/s41591-024-02987-8

[#]COVID19 #PASC #LongCovid

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Written by Hannu Ikonen, MD on 2025-02-01 at 23:01

Scottish Matched Case-Control Study comparing 33,281 Confirmed vs 62,957 Never-Had Controls:

"individuals were followed-up via 6, 12 and 18-month questionnaires and linkage to hospitalization and death records. Of the 31,486 symptomatic infections,1,856 (6%) had not recovered and 13,350 (42%) only partially."

" Previous symptomatic infection was associated with poorer quality of life, impairment across all daily activities and 24 persistent symptoms including breathlessness (OR 3.43, 95% CI 3.29–3.58), palpitations (OR 2.51, OR 2.36–2.66), chest pain (OR 2.09, 95% CI 1.96–2.23), and confusion (OR 2.92, 95% CI 2.78–3.07)."

"Vaccination was associated with reduced risk of seven symptoms."

[#]Covid19 #PASC #LongCovid

https://www.nature.com/articles/s41467-022-33415-5

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Written by Hannu Ikonen, MD on 2025-02-01 at 23:32

Well I won't lie, this headline gets to the meat of it eh lads/lasses?

"Dysautonomia following COVID-19 is not associated with subjective limitations or symptoms but is associated with objective functional limitations"

https://pmc.ncbi.nlm.nih.gov/articles/PMC8656177/

Translate: "Stop being invalidating bio-bigots. It's not hysteria."

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Written by Hannu Ikonen, MD on 2025-02-01 at 23:40

Literal 63 & 68 year old cardiologists I know: "POTS isn't a thing."

Doctors of all ages that follow the science:

"PASC can present with a non-specific constellation of signs and symptoms, (4) some of which appear to be autonomic in nature. These include, but are not limited to, orthostatic intolerance, palpitations, tachycardia, syncope, orthostatic hypertension, labile blood pressures, dizziness, fatigue and exercise intolerance. (5) The most common autonomic diagnoses associated with PASC are orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS), which often follow a viral infection. (5) Other common features of PASC which may be related to autonomic dysfunction include cognitive impairment (often called “brain fog”), headache, insomnia, neuropathic pain, gastrointestinal and genitourinary dysfunction and allergic symptoms suggestive of mast cell activation, such as pruritis, urticaria, flushing, angioedema, wheezing, food sensitivities and others."

Here's 48 more pages for your edification.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9538426

[#]LongCovid #Dysautonomia #PASC #Covid19

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Written by Hannu Ikonen, MD on 2025-02-01 at 23:41

If you think I'm being an asshole to some of my peers, well, if the shoe fits.

They deserve it. Sanctuary & institutional trauma from invalidation in medicine is a thing.

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Written by Hannu Ikonen, MD on 2025-02-01 at 23:47

As soon as some of these doctors stop thinking of themselves as the Gatekeeping Cops of the medical world, the sooner they'll start actually trying to center their care on their patients.

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Toot

Written by ChookMother 🇦🇺🦘 on 2025-02-02 at 00:33

@hannu_ikonen So many people are suffering medical neglect ( and it's been happening for decades re post-viral illness) there's an urgent need for research into why doctors are dismissive and whatever it is in their background, training, culture needs to be corrected. This is just as urgent, in my view, as research into the disease itself.

(I've had me/cfs 30+ years).

[#]MECFS #LongCovid #LongHaulers

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Descendants

Written by Hannu Ikonen, MD on 2025-02-02 at 00:39

@anne_twain Capitalism. Capitalism and internalized Cartesian mind-body dualism elief systems, tbh, imo

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