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Written by Dáire Ó Conchobhair on 2024-11-09 at 19:25

Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium

https://www.nature.com/articles/s41598-024-72262-w

Published Sept. 11, 2024

"The antiviral barrier efficacy and effects on mucociliary function of astodrimer sodium nasal spray (AS-NS) were evaluated and compared with other available nasal sprays—low pH hydroxypropyl methylcellulose (HPMC-NS), iota-carrageenan (Carr-NS), nitric oxide (NO-NS), and povidone iodine (PI-NS)."

"400 µL of the respective nasal spray or PBS were added to each cell culture to emulate application of the sprays to the nasal epithelium. The cultures were incubated for 5 min on a rocking platform to facilitate the formation of a barrier layer. SARS-CoV-2 was then added, at a multiplicity of infection (MOI) of 0.01, in a maximum volume of 400 µL of MEM. The cell cultures were gently rotated to ensure even coverage of both the cells and the nasal spray layer, and then incubated for 4 h at 37 °C in a 5% CO2 environment."

"AS-NS exhibited potent antiviral barrier effects, as evidenced by a 96.6% reduction (1.5 logs) of SARS-CoV-2 infectious virus. A significant reduction in infectious virus was also observed for NO-NS, with a decrease of 90.0% (1 log). Conversely, minimal antiviral activity was observed after exposure to Carr-NS and HPMC-NS."

[#]covid #CovidIsNotOver #MaskUp #NasalSpray #novid

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Written by Dáire Ó Conchobhair on 2024-11-09 at 19:25

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