@_sorcha https://hms.harvard.edu/news/two-phase-infection describes the two phases as "most of the immune reaction is in the lungs" for the first phase and "everywhere else" in the second phase. (There isn't much viral replication in the lungs; it seems to infect your nose and fall into your lungs.)
I don't know which variants have biases towards two phases; I doubt there's anything that isn't not-yet-published-lab-work for the current circulating variants. Experiencing two acute phases is more concerning for severity.
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