I followed a breadcrumb trail on focus detection from the https://forum.image.sc forum to the micromanager source code to the supplemental info of @royerlab Royer et al 2016† and wow! "Part II: Image Quality Metrics in Theory and Practice" (starts on page 9) should really be its own paper, not a buried aside.
https://static-content.springer.com/esm/art%3A10.1038%2Fnbt.3708/MediaObjects/41587_2016_BFnbt3708_MOESM19_ESM.pdf
†: https://www.nature.com/articles/nbt.3708, which you should definitely not use sci-hub to access…
‡: it's also available on the Janelia website: https://www.janelia.org/publication/adaptive-light-sheet-microscopy-long-term-high-resolution-imaging-living-organisms
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