Ancestors

Written by Jake Hamby on 2025-01-30 at 05:42

[#]Ketamine: 50 Years of Modulating the Mind

"Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, its effects on the central nervous system remain incompletely understood. Investigators have leveraged the unique characteristics of ketamine to explore the invariant, fundamental mechanisms of anesthetic action."

https://pmc.ncbi.nlm.nih.gov/articles/PMC5126726/

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Written by Jake Hamby on 2025-01-30 at 05:43

"Although initially developed as an anesthetic, over the past several decades ketamine has been revealed to have greater potential in the field of medicine. A growing body of literature has demonstrated the clinical value of ketamine across diverse settings, with emerging roles in pain medicine and treatment-resistant depression. Concurrently, efforts to uncover the mechanisms underlying ketamine’s actions are providing researchers with new insights into the relationship between

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Written by Jake Hamby on 2025-01-30 at 05:43

consciousness and anesthesia.

Since the first clinical report in 1966, ketamine has become arguably the most unique anesthetic agent used today and also one of the most promising and exciting in terms of its potential."

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Written by Jake Hamby on 2025-01-30 at 05:46

I did not realize that ketamine was synthesized because they were trying to find a drug that was like PCP but didn't make you psychotic. Ketamine, originally CI-581, was synthesized as a structural analog at 1/10 the potency of its parent drug, PCP.

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Toot

Written by kcarruthers on 2025-01-30 at 05:48

@jhamby wow 😮

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Descendants

Written by 64 Islands Aroha Cooperative on 2025-01-30 at 06:00

@kcarruthers @jhamby right?

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