Ancestors

Written by Dan Goodman on 2025-01-27 at 18:08

Thinking about big science, the human genome project looms large. I'm not an expert so: did this project fulfil its potential? From what I've seen, it seems the major achievement was development of sequencing tech and a focus on open data. Otherwise, people still talking in terms of potential value?

Apologies in advance if this comes across as ignorant, I really don't know much about genetics.

=> More informations about this toot | More toots from neuralreckoning@neuromatch.social

Written by Sharlatan on 2025-01-27 at 23:35

Was #Inria involved in HGP where the main implementation of #Guix for reproducible research in bioinformatics was urged?

@khinsen @civodul

=> More informations about this toot | More toots from sharlatan@mastodon.social

Written by Simon Tournier on 2025-01-28 at 00:57

@sharlatan To me knowledge, HGP is older than Guix and it’s more CNRS than Inria; I don’t know if INRIA had joined the HGP party.

@civodul @khinsen

=> More informations about this toot | More toots from zimoun@sciences.re

Toot

Written by Konrad Hinsen on 2025-01-28 at 07:04

@zimoun HGP ended in 2003, Guix started in 2012. In France, CNRS and CEA participated in HGP. I don't know about Inria.

@sharlatan @civodul

=> More informations about this toot | More toots from khinsen@scholar.social

Descendants

Written by Ludovic Courtès on 2025-01-28 at 09:38

@khinsen @sharlatan @zimoun What’s HGP? :-)

=> More informations about this toot | More toots from civodul@toot.aquilenet.fr

Written by Guillaume Gaullier ❄️🔬 on 2025-01-28 at 09:44

@civodul Human Genome Project. More info here: https://en.wikipedia.org/wiki/Human_Genome_Project

@khinsen @sharlatan @zimoun

=> More informations about this toot | More toots from Guillawme@fediscience.org

Written by Ludovic Courtès on 2025-01-28 at 12:50

@Guillawme @zimoun @sharlatan @khinsen Oh thanks. So a deployment tool was developed in the context of HGP?

=> More informations about this toot | More toots from civodul@toot.aquilenet.fr

Written by Guillaume Gaullier ❄️🔬 on 2025-01-29 at 13:32

@civodul A deployment tool specifically, not that I know.

But a lot of bioinformatics things were developed for this project. A prominent example is genome assemblers, both the implementations and the underlying theory. They are needed because of the way the sequencing is performed: it's called "shotgun sequencing" and produces many short overlapping fragments (called "reads") that are then assembled into the final sequence by identifying the overlaps.

Other threads from the first post mention other advances from the HGP, of different sorts (technical, scientific, etc.). It's an interesting read, even though not about a deployment tool.

@zimoun @sharlatan @khinsen

=> More informations about this toot | More toots from Guillawme@fediscience.org