Toots for datum@zeroes.ca account

Written by datum (n=1) on 2025-02-02 at 05:48

Trudeau in questions called out the gas industry for leverage then immediately repeated with additional emphasis that he and all premiers agreed that no area or industry should bear a disproportionate burden, with subtle emphasis on industry, as if he can't believe how easy it is to get away with saying this so directly

which is code for O&G bailouts

just FYI

[#]politics #canada #trade #oilAndGas #fossilFuels #tarrifs

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-02 at 04:52

search is so broken

me: "keyword1 keyword2 keyword3"

searches: naw 0 hits

me: keyword1 keyword2 keyword3

Searches: ok here's a page of results mostly titled "keyword1 keyword2 keyword3" verbatim

eww

why not just say "we don't allow multiple word queries any more" don't return 0 results? Eww.

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-02 at 01:43

CBC must have budget cuts or brain fog in their editing department

https://www.cbc.ca/news/politics/trump-tariffs-canada-february-1-1.7447829 - major story, of first order national importance

"Steelmakers could feel the pinch with Quebec aluminum, widely used by U.S. industry, being 25 per cent more expensive" - uh, that's not how steel works

(US steelmakers will make bank, as US users of metals re-cost designs to use steel instead of aluminum)

"illegal migrants" - existing is not illegal, they're undocumented migrants

I would have other meaningful suggestions if the author were remotely likely to receive them

"Follow J.P. on X" the byline suggests - naw, you come here, and I and others will give you detailed engagement that you could only dream of there

or stay over there as you write increasingly negative portrayals of the owner's machinations, cool cool

[#]CBC #Canada #Politics #fundTheCBC

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-01 at 20:35

welcome to fedi, @silverTonguedc4t

lots of covid-competent accounts at https://zeroes.ca/explore/suggestions in case that's helpful while you find initial folks worth following

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-01 at 09:21

Someone tells Bonny Henry to do her job

Bonny Henry responds "I know how challenging it is to feel like you're at risk"

It's not challenging to FEEL that way

It's challenging to BE at risk

But acknowledging that there is a risk from COVID-19 is too much for Bonny Henry to likely accomplish in this lifetime

[#]COVID #COVIDIsNotOver #BC #BCPoli #COVID19 #BCPolitics

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-01 at 09:10

This isn't in the news so unfortunately coverage is this or nothing: https://zeroes.ca/@frozen@bird.makeup/113921143096086815

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-01 at 08:11

[edit: has been done. Thanks WearieBonnie!]

Are you on Bluesky or that other one?

Could you please do a small favour if so?

Please tell Dr. Tara Moriarty that "Engagements: 20" is literally less engagement than 300-follower accounts get on Mastodon when they quote and forward her work?

(searchable accounts including mine make this trivial to verify)

that's re: https://zeroes.ca/@moriartylab@bird.makeup/113927575739710810 - Dr. Moriarty is apparently considering "when to leave permanently"

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-02-01 at 02:34

here's a track for all you fatigue sufferers out there,

"tried to raise her nice, but she couldn't even raise her head, and the day she ain't dead tired, that'll be the day she's dead. She's too tired to eat, too tired to sin ... she's half asleep but she's even too tired to yawn; she's been strictly horizontal ever since the day she was born"

https://archive.org/details/78_the-lady-in-bed_hot-lips-page-and-his-orchestra-lucky-thompson-hot-lips-page-vic-di_gbia0066029b

[#]Fatigue #PwLC #music #blues

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 21:00

From the official BC health care long covid website, https://www.longcovidbc.ca/

"Provincial and Territorial Resources (0)"

Yes. Yes we know. SIgh.

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 20:49

I would welcome references re: effective dosages for LC-associated dyspnea if anyone has done that research already

not a doc so my keyword selections are likely ill-chosen

@askazero

[#]askingForMedicalAdviceOnline #definitelySmart

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 20:41

⚡ Lightning overview of N-acetylcysteine (NAC) for Long COVID with difficulty breathing (dyspnea) 🌩️

TLDR: NAC seems to help LC/dyspnea and is relatively safe.

WHY:

A small study found "three out of 3 (100 %) of the PASC/LC patients supplementing their diet with NAC decreased vWF values to normal levels at the time of subsequent evaluations, whereas none (0 %) of the 6 symptomatic PASC/LC control patients did so" [0]

REVIEW:

"N-acetylcysteine reduces severity and mortality in COVID-19 patients" right in the title [8]

"mortality was the most meaningful outcome of NAC therapeutic efficacy in patients with COVID-19 [...] mortality was significantly reduced in the NAC-treated group compared to the placebo group [RR, 0.65; 95% CI: 0.56 to 0.75; p-value 0.0001]" [8]

"Two grams of oral or IV GSH, a precursor to NAC therapy, has effectively reduced dyspnea in COVID-19 patients. Later on, in a large cohort study of 19,208 hospitalized COVID-19 cases, 2,071 of whom were treated with 600 mg/kg oral NAC, mortality was significantly reduced."

"mice treated with NAC presented markedly reduced CS-induced pulmonary injury and ameliorated CS-induced pulmonary fibrosis and inflammation" [2]

"After pretreatment with NAC at low, moderate, and high concentration, respectively, intracellular reactive oxygen species (ROS)" [2]

"N-acetyl cysteine is likely safe for most adults" [3]

"properties of NAC include enhancing glutathione S-transferase activity, repleting glutathione, scavenging free radicals, and stabilizing protein structures by crosslinking cysteine disulfide molecules along with its antioxidant, anti-inflammatory, and mucolytic properties" [4]

Back in 2021:

"Collectively this data supports the notion that 1200 mg of oral NAC can effectively reduce ROS production without compromising phagocytosis of SARS-Cov-2 in neutrophils" [5]

"N-acetylcysteine (NAC) is inexpensive, has very low toxicity, has been FDA approved for many years, and has the potential to improve therapeutic strategies for COVID-19. [...] Potential therapeutic benefits of NAC include, extracellularly scavenging ROS radicals, replenishing intracellular GSH, suppression of cytokine storm, and T cell protection, thus mitigating inflammation and tissue injury" [5]

"in in vivo experiments, NAC inhibited several profibrotic mechanisms in murine models" [6]

In humans, "NAC may restore defective autophagy [...] NAC may prevent and eliminate biofilms resulting from airway infections, particularly of Pseudomonas aeruginosa" [6]

"In COPD, beneficial effects of NAC have not been clearly confirmed in the clinical studies, probably due to insufficient doses, short time of observation, inactivation of NAC by oxidative stress, and/or the choice of inadequate outcome parameters" [6]

"supplementing GlyNAC (combination of glycine and N-acetylcysteine, a cysteine donor) for a relatively short period of 14 days improves/corrects GSH deficiency in OA, HIV-patients and diabetic patients, and these data suggest the possibility that similar supplementation of GlyNAC in COVID-19 patients could improve GSH deficiency" [7]

"Glutathione (GSH) is the most abundant" antioxidant, and "Compared to controls, RBC concentrations of total-GSH (tGSH) and reduced-GSH (rGSH) in COVID-19 patients were 60% lower"; "Because GlyNAC (combination of glycine and N-acetylcysteine) supplementation has been shown in clinical trials to rapidly improve GSH deficiency, OxS and oxidant damage, GlyNAC supplementation has implications for combating these defects" [7]

Safety-wise, in "Forty-one articles where NAC has been used at 600 mg and above, up to 3000 mg/day, and with a specific report on safety, were considered. [...] the safety profile was similar at both the high and standard doses with the oral formulation; gastrointestinal symptoms were reported but they were no more common than in the control group." [9]

"N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia" [10] is not COVID-19 specifically but if LC-driven oxidative stress is causally contributing to dyspnea then that result applies.

Trial check:

https://clinicaltrials.gov/study/NCT04545008 - stopped due to poor accrual

https://clinicaltrials.gov/study/NCT04455243 - never recruited

https://clinicaltrials.gov/study/NCT04466657 - never enrolled

https://clinicaltrials.gov/study/NCT04370288 - never ran?

https://clinicaltrials.gov/study/NCT04374461 - active, estimated completion 2025-05

https://clinicaltrials.gov/study/NCT04419025 - completed, unpublished - likely signifies a lack of result

[0] https://www.sciencedirect.com/science/article/pii/S2352578925000074

[1] https://www.sciencedirect.com/science/article/pii/S0753332225000496

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6639458/

[3] https://medlineplus.gov/druginfo/natural/1018.html

[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC8211525/

[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC7649937/

[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC10526097/

[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC8773164/

[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC10390689/

[9] https://pmc.ncbi.nlm.nih.gov/articles/PMC7892733/

[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC6250560/

Note I am NOT a doctor, this is a lay review!

[#]SARSCoV2 #COVID #COVID19 #CovidIsNotOver #dyspnea #breathing #review #science #LongCOVID #LC

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 19:40

Excerpts from "N-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID" [0]

It was a tiny study, but 3/3 returned to normal range on NAC and 0/6 not on NAC, and the data is longitudinal, with clear vWF before/after NAC supplemetation!

"plasmatic levels of vWF were collected during the COVID-19 pandemic in PASC/LC patients at the time of follow up visits as part of their blood-workup monitoring, we were also able to evaluate and compare vWF levels before and after starting NAC treatment to those detected in a control group of randomly selected gynecologic patients with PASC/LC symptoms who did not use the supplement"

They "found patients reporting regular use of NAC to subjectively demonstrate improvement in SOB, brain fog and fatigue. Of interest, although we noticed the plasmatic concentration of vWF to decrease with time in both groups of patients, only NAC supplementers were able to normalize their vWF levels after treatment (ie, 3 out of 3), whereas 0 % of the control PASC/LC gynecologic patients did so (ie, 0 out of 6) regardless to their baseline starting level of vWF or follow up time. Importantly, in our small series, subjective improvement in performance status and decrease/normalization in the levels of vWF were detected even in PASC/LC patient symptomatic for years."

Also that paper's intro is 🤩 fantastic and full of up to date references, independent of the power of their reported results.

[0] https://www.sciencedirect.com/science/article/pii/S2352578925000074

h/t https://zeroes.ca/@trendless/113924358608441600

[#]SARSCoV2 #COVID #COVID19 #CovidIsNotOver #dyspnea #breathing #review #science #LongCOVID #LC

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 18:03

@ben @ProPublica

BREAKING

there's a whistleblower who just posted this https://theconcernedbird.substack.com/p/elon-musks-and-xs-role-in-2024-election

this really seems up your alley

[edit: these breadcrumbs are freaking WILD it's more like a trail of cakes that fell off the truck - https://elizaos.github.io/eliza/docs/core/characterfile/ - not subtle at ALL]

[edit 2: by 'breaking' I mean 'no media coverage yet', also anyone can throw cakes off a truck so ProPublica is tagged because their work corroborates with public record evidence]

[#]breakingNews

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 16:40

yes that's a colon not a semicolon in the CW

https://hackers.town/@lmorchard/113920124327091051

guess that's how I'll have to (fucking) phrase things from now on in search engines?

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-31 at 01:43

anecdotes from BC:

➡️ lots of folks masking

➡️ more N95s than baggy blues!

➡️ lots of folks coughing (lots and lots)

➡️ almost nobody sneezing though!?

➡️ "two colds/flus in jan and another now" in a purportedly relatively healthy person

➡️ visibly sick kids coming home from school this afternoon means they probably went in that way this morning

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-30 at 23:17

"in 2017, the pilots' union for American Airlines forced their bosses into a raise. Wall Street freaked out and tanked AA's stock. Analysts for big banks were outraged. Citi's Kevin Crissey summed up the situation perfectly, in a fuming memo: "This is frustrating. Labor is being paid first again. Shareholders get leftovers":" [1]

[1] https://pluralistic.net/2025/01/29/which-side-are-you-on-2/#strike-three-yer-out

[#]CoryDoctorow #power #politics #prices #Economics

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-30 at 23:15

"The cost and price of a good or service is the tangible expression of power. It is a matter of politics, not economics." [1]

yes yes I know this is fulfilling the stereotype of quoting Cory Doctorow on Mastodon

what can you do?

truth is truth

[1] https://pluralistic.net/2025/01/29/which-side-are-you-on-2/

[#]CoryDoctorow #power #politics #prices #economics

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-30 at 20:25

PS - sorry for boosting from bird.makeup, I will try to only do so for AJ Leonardi and Tara Moriarty

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-30 at 06:20

Hm, kinda dislike that followERs count, but not followING count, is displayed in mastodon's new profile summary hover UI (v4.3.3+glitch)

it sends the message that one number matters more than the other

and a big part of fedi's effectiveness is that there has been less reward feedback for "influencer" than for "prominent community member"

so I distrust the social impact of emphasizing follower count

[#]Fediverse

=> More informations about this toot | View the thread

Written by datum (n=1) on 2025-01-30 at 06:03

"Robust hybrid immunity" - robust against political criticism, not against infection

[#]BC #BCPoli #publicHealth

=> More informations about this toot | View the thread

=> This profile with reblog | Go to datum@zeroes.ca account